Positive peritoneal cytology and its prognostic value in endometrioid adenocancer confined to the uterus
The aim of this study was to evaluate the prognostic significance of peritoneal cytology in patients with endometrioid adenocarcinoma limited to the uterus.
A retrospective study was performed on 46 patients with surgically staged endometrioid adenocarcinoma that was histologically confined to the uterus. Patients who had negative nodes, disease localized to the uterus and endometrioid subtype were included. The Chi-square (χ 2) test was used for statistical analysis. Disease free survival rates calculated by the Kaplan-Meier method, and log-rank test was used for comparison. Stepwise Cox proportional hazard model was used to assess the independent prognostic and predictive factors affecting disease free survival.
The median duration of the follow-up period was 36 months (1–104 months). Peritoneal cytology was positive in 4 patients (8.7%). The disease-free survival rate at 36 months was 50% among patients with positive cytology, compared with that of 92.9% among patients with negative cytology, and the difference was significant (log-rank, P = 0.036). Multivariate analysis revealed that peritoneal cytology was independent prognostic factor (P = 0.016; OR: 9.0; 95% Cl: 1.497–54.179) of disease-free survival in patients with endometrial carcinoma confined to the uterus.
We concluded that the presence of positive peritoneal cytology is an independent prognostic factor in patients with endometrial carcinoma confined to the uterus.
J. METINDIR, G. BILIR DILEK
Endometrioid adenocarcinoma, Peritoneal cytology, Prognostic factor